Design, Synthesis and Anti-Depressant Activity of Some Novel Coumarin Derivatives

The present research work deals with the synthesis, characterization and to evaluate the synthesized compound for antidepressant activity of a series of coumarin derivatives. Basic coumarin is prepared by Perkin reaction, which further reacted with aryl thiourea by cyclization reaction leads to produce 3-(2-(phenylaminothiazol-4-yl)-2H-chromen-2-one. Totally twelve compounds, were synthesized by conventional method and their purity was determined by TLC and they were characterized by IR and NMR spectroscopic methods. Antidepressant activity of all the synthesized compounds was evaluated by despair swim test by using Sprague Dawley Rats. Standard drug Imipramine was used as the control. In the despair swim test, all the synthesized derivatives showed antidepressant activity. Among them three Compounds (A4, A5 and A9) showed significant antidepressant activity comparing with control drug imipramine and some compound shows mild antidepressant activity. These results are useful for the further investigation in the future.